USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: PABP1_HUMAN USC-OGP 2-DE database:  PABP1_HUMAN PABP1_HUMAN General information about the entry View entry in simple text format Entry name PABP1_HUMAN Primary accession number P11940 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Polyadenylate-binding protein 1; Short=PABP-1; Short=Poly(A)-binding protein 1;. Gene name Name=PABPC1 Synonyms=PAB1, PABP1, PABPC2 Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1121: pI=5.77; Mw=83686 Cross-references UniProtKB/Swiss-Prot P11940; PABP1_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PABP1_HUMAN Primary accession number P11940 Secondary accession number(s) Q15097 Q93004 Sequence was last modified on  July 15, 1998 (version 2) Annotations were last modified on  March 15, 2017 (version 213) Name and origin of the protein Description RecName: Full=Polyadenylate-binding protein 1; Short=PABP-1; Short=Poly(A)-binding protein 1; Gene name Name=PABPC1 Synonyms=PAB1, PABP1, PABPC2 Encoded on Name=PABPC1; Synonyms=PAB1, PABP1, PABPC2 Keywords 3D-structure; Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Methylation; mRNA processing; mRNA splicing; Nonsense-mediated mRNA decay; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding; Spliceosome. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL Y00345; CAA68428.1; -; mRNA EMBL U68104; AAD08718.1; -; Genomic_DNA EMBL U68093; AAD08718.1; JOINED; Genomic_DNA EMBL U68094; AAD08718.1; JOINED; Genomic_DNA EMBL U68095; AAD08718.1; JOINED; Genomic_DNA EMBL U68097; AAD08718.1; JOINED; Genomic_DNA EMBL U68098; AAD08718.1; JOINED; Genomic_DNA EMBL U68099; AAD08718.1; JOINED; Genomic_DNA EMBL U68100; AAD08718.1; JOINED; Genomic_DNA EMBL U68101; AAD08718.1; JOINED; Genomic_DNA EMBL U68102; AAD08718.1; JOINED; Genomic_DNA EMBL U68103; AAD08718.1; JOINED; Genomic_DNA EMBL AP001205; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL BC015958; AAH15958.1; -; mRNA EMBL BC023520; AAH23520.1; -; mRNA EMBL Z48501; CAA88401.1; -; mRNA CCDS CCDS6289.1; -. [P11940-1]; . PIR A93668; DNHUPA; . PIR S52491; S52491; . RefSeq NP_002559.2; NM_002568.3. [P11940-1]; . RefSeq XP_005250918.1; XM_005250861.2. [P11940-1]; . UniGene Hs.387804; -; . PDB 1CVJ; X-ray; 2.60 A; A/B/C/D/E/F/G/H=1-190 PDB 1G9L; NMR; -; A=498-636 PDB 1JGN; NMR; -; A=544-636 PDB 1JH4; NMR; -; A=544-636 PDB 2K8G; NMR; -; A=90-182 PDB 2RQG; NMR; -; B=541-623 PDB 2RQH; NMR; -; B=541-623 PDB 2X04; X-ray; 1.49 A; A/B=545-619 PDB 3KTP; X-ray; 1.50 A; A=544-626 PDB 3KTR; X-ray; 1.70 A; A=544-626 PDB 3KUI; X-ray; 2.30 A; A=544-626 PDB 3KUJ; X-ray; 1.40 A; A=544-626 PDB 3KUR; X-ray; 2.50 A; A/B/C/D/E/F/G/H=544-617 PDB 3KUS; X-ray; 1.40 A; A/B=544-626 PDB 3KUT; X-ray; 1.50 A; A/B=544-626 PDB 3PKN; X-ray; 1.80 A; A=544-626 PDB 3PTH; X-ray; 1.70 A; A=543-621 PDB 4F02; X-ray; 2.00 A; A/D=1-190 PDB 4F25; X-ray; 1.90 A; A=99-199 PDB 4F26; X-ray; 2.00 A; A=99-199 PDB 5DX1; X-ray; 1.93 A; F/G/H/I=449-466 PDB 5DX8; X-ray; 1.94 A; E/F/G/H=449-466 PDB 5DXA; X-ray; 2.07 A; F/G/I=449-466 PDBsum 1CVJ; -; . PDBsum 1G9L; -; . PDBsum 1JGN; -; . PDBsum 1JH4; -; . PDBsum 2K8G; -; . PDBsum 2RQG; -; . PDBsum 2RQH; -; . PDBsum 2X04; -; . PDBsum 3KTP; -; . PDBsum 3KTR; -; . PDBsum 3KUI; -; . PDBsum 3KUJ; -; . PDBsum 3KUR; -; . PDBsum 3KUS; -; . PDBsum 3KUT; -; . PDBsum 3PKN; -; . PDBsum 3PTH; -; . PDBsum 4F02; -; . PDBsum 4F25; -; . PDBsum 4F26; -; . PDBsum 5DX1; -; . PDBsum 5DX8; -; . PDBsum 5DXA; -; . ProteinModelPortal P11940; -; . SMR P11940; -; . BioGrid 117939; 238; . DIP DIP-31613N; -; . IntAct P11940; 99; . MINT MINT-96210; -; . STRING 9606.ENSP00000313007; -; . BindingDB P11940; -; . ChEMBL CHEMBL1293286; -; . iPTMnet P11940; -; . PhosphoSitePlus P11940; -; . SwissPalm P11940; -; . BioMuta PABPC1; -; . DMDM 3183544; -; . EPD P11940; -; . MaxQB P11940; -; . PaxDb P11940; -; . PeptideAtlas P11940; -; . PRIDE P11940; -; . DNASU 26986; -; . Ensembl ENST00000318607; ENSP00000313007; ENSG00000070756. [P11940-1]; . GeneID 26986; -; . KEGG hsa:26986; -; . UCSC uc003yjs.2; human. [P11940-1]; . CTD 26986; -; . DisGeNET 26986; -; . GeneCards MIR7705; -; . GeneCards PABPC1; -; . HGNC HGNC:8554; PABPC1; . HPA CAB011536; -; . HPA HPA045423; -; . HPA HPA067156; -; . MIM 604679; gene; . neXtProt NX_P11940; -; . OpenTargets ENSG00000070756; -; . PharmGKB PA32880; -; . eggNOG KOG0123; Eukaryota; . eggNOG ENOG410XR5X; LUCA; . GeneTree ENSGT00760000118913; -; . HOGENOM HOG000217922; -; . HOVERGEN HBG002295; -; . InParanoid P11940; -; . KO K13126; -; . OMA XAVDEMN; -; . OrthoDB EOG091G03ZE; -; . PhylomeDB P11940; -; . TreeFam TF300458; -; . Reactome R-HSA-156827; L13a-mediated translational silencing of Ceruloplasmin expression; . Reactome R-HSA-429947; Deadenylation of mRNA; . Reactome R-HSA-450408; AUF1 (hnRNP D0) binds and destabilizes mRNA; . Reactome R-HSA-72649; Translation initiation complex formation; . Reactome R-HSA-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC); . Reactome R-HSA-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC); . SIGNOR P11940; -; . ChiTaRS PABPC1; human; . EvolutionaryTrace P11940; -; . GeneWiki PABPC1; -; . GenomeRNAi 26986; -; . PMAP-CutDB P11940; -; . PRO PR:P11940; -; . Proteomes UP000005640; Chromosome 8; . Bgee ENSG00000070756; -; . CleanEx HS_PABPC1; -; . ExpressionAtlas P11940; baseline and differential; . Genevisible P11940; HS; . GO GO:0071013; C:catalytic step 2 spliceosome; IDA:UniProtKB; . GO GO:0005737; C:cytoplasm; TAS:UniProtKB; . GO GO:0036464; C:cytoplasmic ribonucleoprotein granule; IDA:ParkinsonsUK-UCL; . GO GO:0010494; C:cytoplasmic stress granule; IDA:UniProtKB; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005925; C:focal adhesion; IDA:UniProtKB; . GO GO:0030529; C:intracellular ribonucleoprotein complex; IDA:UniProtKB; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005634; C:nucleus; IDA:MGI; . GO GO:0003730; F:mRNA 3'-UTR binding; IDA:UniProtKB; . GO GO:0000166; F:nucleotide binding; IEA:InterPro; . GO GO:0008143; F:poly(A) binding; TAS:UniProtKB; . GO GO:0008266; F:poly(U) RNA binding; IDA:MGI; . GO GO:0008022; F:protein C-terminus binding; IPI:UniProtKB; . GO GO:0003723; F:RNA binding; IDA:UniProtKB; . GO GO:0008494; F:translation activator activity; TAS:UniProtKB; . GO GO:0031047; P:gene silencing by RNA; ISS:UniProtKB; . GO GO:0006378; P:mRNA polyadenylation; TAS:UniProtKB; . GO GO:0000398; P:mRNA splicing; via spliceosome; IC:UniProtKB GO GO:0048255; P:mRNA stabilization; TAS:UniProtKB; . GO GO:2000623; P:negative regulation of nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; IDA:UniProtKB GO GO:0000184; P:nuclear-transcribed mRNA catabolic process; nonsense-mediated decay; TAS:Reactome GO GO:0000289; P:nuclear-transcribed mRNA poly(A) tail shortening; TAS:Reactome; . GO GO:1900153; P:positive regulation of nuclear-transcribed mRNA catabolic process; deadenylation-dependent decay; ISS:UniProtKB GO GO:0060213; P:positive regulation of nuclear-transcribed mRNA poly(A) tail shortening; ISS:UniProtKB; . GO GO:0045070; P:positive regulation of viral genome replication; IMP:UniProtKB; . GO GO:0043488; P:regulation of mRNA stability; TAS:Reactome; . GO GO:0006413; P:translational initiation; TAS:Reactome; . Gene3D 1.10.1900.10; -; 1; . Gene3D 3.30.70.330; -; 4; . InterPro IPR012677; Nucleotide-bd_a/b_plait; . InterPro IPR006515; PABP_1234; . InterPro IPR002004; PABP_HYD; . InterPro IPR000504; RRM_dom; . InterPro IPR003954; RRM_dom_euk; . Pfam PF00658; PABP; 1; . Pfam PF00076; RRM_1; 4; . SMART SM00517; PolyA; 1; . SMART SM00360; RRM; 4; . SMART SM00361; RRM_1; 3; . SUPFAM SSF54928; SSF54928; 2; . SUPFAM SSF63570; SSF63570; 1; . TIGRFAMs TIGR01628; PABP-1234; 1; . PROSITE PS51309; PABC; 1; . PROSITE PS50102; RRM; 4; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]